2,4-Dibromo-thiazole-5-carbaldehyde → 2,4-Dibromothiazole-5-methanol

2,4-Dibromo-thiazole-5-carbaldehyde (2.0 g, 7.4 mmol) in methanol (80 mL) was treated with NaBH4 (419 mg, 11.0 mmol). The reaction mixture was stirred at rt overnight, quenched with 10% NaOH, diluted with water and extracted with ethyl acetate (2×). The solvent was removed, and the resulting residue was chromatographed using hexane/ethyl acetate (3:1) to give the title compound (1.84 g, 91%). MS (DCI/NH3) m/z 274 (M)+. 1H NMR (500 MHz, CDCl3) δ ppm 2.11 (s, 1H) 4.78 (s, 2H).

1. customquenched with 10% NaOH
2. additiondiluted with water
3. extractionextracted with ethyl acetate (2×)
4. customThe solvent was removed
5. customthe resulting residue was chromatographed

ORD 기록

ord-7ac8d0d874d84bbda6bc028bddfb0286

출처 데이터셋

uspto-grants-2010_04

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US07704997B1