Pyrrolidine → HCID 68582180, 화합물

반응식

[F:1][C:2]1[N:9]=[C:8](F)[C:7]([F:11])=[CH:6][C:3]=1[C:4]#[N:5].[NH:12]1[CH2:16][CH2:15][CH2:14][CH2:13]1>>[F:1][C:2]1[N:9]=[C:8]([N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)[C:7]([F:11])=[CH:6][C:3]=1[C:4]#[N:5]

참가 물질

반응물 2

HCID 31268Pyrrolidine

HCID 404271652,5,6-Trifluoronicotinonitrile

생성물 1

HCID 68582180HCID 68582180, 화합물수율 57%

실험 절차

Prepared in 57% yield from 2,5,6-Trifluoro-nicotinonitrile and pyrrolidine according to the procedure described for Example 178A. 1H NMR (DMSO-d6) δ 1.85-1.93 (m, 4H), 3.55-3.62 (m, 4H), 8.01 (dd, J=12.2, 6.8 Hz, 1H).

출처 및 근거

ORD 기록: ord-d6f8b91980634664976f07bca4ae9c74
출처 데이터셋: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07704997B1

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