Hydrochloric Acid → HCID 178430834, 화합물

HRID 645693노트

반응식

HRID 645693 반응식
CO[CH:3](OC)[CH:4](Cl)[CH3:5].Cl.CC([O-])=O.[Na+].[NH2:15][C:16]1[NH:21][C:20](=[O:22])[NH:19][C:18](=[O:23])[CH:17]=1>O>[CH3:5][C:4]1[C:17]2[C:18]([OH:23])=[N:19][C:20]([OH:22])=[N:21][C:16]=2[NH:15][CH:3]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric Acid2회HCID 701206-AminouracilHCID 517045Sodium Acetate2회HCID 51528542-Chloropropionaldehyde dimethyl acetal

생성물 1

HCID 178430834HCID 178430834, 화합물수율 94%

시약·촉매·용매 1

HCID 962Water용매2회

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온도
95 °C

실험 절차

To a mixture of 2-chloropropionaldehyde dimethyl acetal (5.84 g, 42.1 mmol) in H2O (26 mL) was added conc. HCl (1 mL). After heating at 95° C. for 15 min (or until the solution turns homogenous), NaOAc (5.2 g) was added to neutralize the excess HCl. The resulting solution was then transferred to a separate flask containing a suspension of 6-aminouracil (4 g, 31.5 mmol) and NaOAc (2.6 g) in H2O (52 mL). After heating the mixture at reflux overnight, the reaction was cooled and the precipitates were collected by filtration to give 5-methyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diol (4.8 g, 94% yield).

후처리

  1. additionwas added
  2. customThe resulting solution was then transferred to a separate flask
  3. additioncontaining
  4. temperatureAfter heating the mixture
  5. temperatureat reflux overnight
  6. temperaturethe reaction was cooled
  7. filtrationthe precipitates were collected by filtration

출처 및 근거

ORD 기록
ord-a9df538fcb11438db3783aef53306f67
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07705004B2

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