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Chlorotrimethylsilane → 6-(2-(1H-indazol-6-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-2,2-dimethyl-2H-benzo[b][1,4]oxazin-3(4H)-one

HRID 645698
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인쇄 미리보기

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HRID 645698 반응식
Cl[C:2]1[N:3]=[C:4]([NH:11][C:12]2[CH:24]=[CH:23][C:15]3[O:16][C:17]([CH3:22])([CH3:21])[C:18](=[O:20])[NH:19][C:14]=3[CH:13]=2)[C:5]2[CH:10]=[CH:9][NH:8][C:6]=2[N:7]=1.[NH2:25][C:26]1[CH:34]=[C:33]2[C:29]([CH:30]=[N:31][NH:32]2)=[CH:28][CH:27]=1.C[Si](Cl)(C)C>C(O)CCC>[NH:32]1[C:33]2[C:29](=[CH:28][CH:27]=[C:26]([NH:25][C:2]3[N:3]=[C:4]([NH:11][C:12]4[CH:24]=[CH:23][C:15]5[O:16][C:17]([CH3:22])([CH3:21])[C:18](=[O:20])[NH:19][C:14]=5[CH:13]=4)[C:5]4[CH:10]=[CH:9][NH:8][C:6]=4[N:7]=3)[CH:34]=2)[CH:30]=[N:31]1
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참가 물질

5

반응물 3

HCID 6397ChlorotrimethylsilaneHCID 814231H-Indazol-6-amineHCID 866280386-(2-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-2,2-dimethyl-2H-benzo[b][1,4]oxazin-3(4H)-one

생성물 1

HCID 251960136-(2-(1H-indazol-6-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-2,2-dimethyl-2H-benzo[b][1,4]oxazin-3(4H)-one수율 6.2%

시약·촉매·용매 1

HCID 263
1-Butanol
용매

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온도
115 °C

실험 절차

To a mixture of 6-(2-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-2,2-dimethyl-2H-benzo[b][1,4]oxazin-3(4H)-one (0.050 g) inn-butyl alcohol (0.6 mL) was added 6-aminoindazole (0.028 g) and trimethylsilyl chloride (TMSCl) (0.013 mL). After heating at 115° C. for 15 h, the mixture was purified by preparative HPLC to give 6-(2-(1H-indazol-6-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-2,2-dimethyl-2H-benzo[b][1,4]oxazin-3(4H)-one (0.004 g, MS [MH] 441.1) (Compound 16-1).

후처리

  1. customthe mixture was purified by preparative HPLC

출처 및 근거

ORD 기록
ord-58013d8bb578455dbc65aaca5e1fd0e3
출처 데이터셋
uspto-grants-2010_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07705004B2

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