Sodium hydride → HCID 13670536, 화합물

HRID 64580노트

반응식

HRID 64580 반응식
[OH:1][C:2]1[CH:12]=[CH:11][C:5]([O:6][CH:7]([CH3:10])[C:8]#[N:9])=[CH:4][CH:3]=1.[H-].[Na+].[H][H].Cl[C:18]1[CH:27]=[N:26][C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[N:19]=1>CN(C)C=O.O>[N:19]1[C:20]2[C:25](=[CH:24][CH:23]=[CH:22][CH:21]=2)[N:26]=[CH:27][C:18]=1[O:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][CH:7]([CH3:10])[C:8]#[N:9])=[CH:11][CH:12]=1

참가 물질

7

반응물 4

HCID 24758Sodium hydrideHCID 2389382-ChloroquinoxalineHCID 106070872-(4-hydroxyphenoxy)propanenitrileHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 13670536HCID 13670536, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매2회

반응 조건

온도
130 °C

실험 절차

In a nitrogen atmosphere, add a solution of 4.9 g (0.03 mole) 2-(4-hydroxyphenoxy)propionitrile in 20 cc dimethylformamide to 1.5 g sodium hydride (0.03 mole) in 20 cc dimethylformamide. When the evolution of hydrogen ceases, add 4.9 g (0.03 mole) 2-chloroquinoxaline. Heat at approximately 130° C. until the reaction is complete. Pour into water and extract the product in ether. Dry the ethereal extracts and concentrate to yield the desired nitrile.

후처리

  1. extractionextract the product in ether
  2. customDry the ethereal extracts
  3. concentrationconcentrate

출처 및 근거

ORD 기록
ord-cf3057c5907343aeb16919d522630d49
출처 데이터셋
uspto-grants-1986_09
특허 번호
US04609396

반응 노트

불러오는 중…