Dimethylformamide → HCID 70469256, 화합물

HRID 64583

반응식

HRID 64583 반응식
[OH:1][C:2]1[CH:19]=[CH:18][C:5]([O:6][C:7]2[C:16](C)=[N:15][C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[N:8]=2)=[CH:4][CH:3]=1.[H-].[Na+].[H][H].Br[CH:25]([CH3:32])[CH:26]=[CH:27][C:28]([O:30][CH3:31])=[O:29].[CH3:33]N(C)C=O>O>[CH3:33][C:7]1([O:6][C:5]2[CH:4]=[CH:3][C:2]([O:1][CH:25]([CH3:32])[CH:26]=[CH:27][C:28]([O:30][CH3:31])=[O:29])=[CH:19][CH:18]=2)[N:8]=[C:9]2[C:14]([CH:13]=[CH:12][CH:11]=[CH:10]2)=[N:15][CH2:16]1

참가 물질

7

반응물 5

HCID 6228Dimethylformamide2회HCID 24758Sodium hydrideHCID 136705382-(4-Hydroxyphenoxy)-3-methylquinoxalineHCID 54128087Methyl 4-bromo-2-pentenoateHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 70469256HCID 70469256, 화합물

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
80 °C

실험 절차

In a nitrogen atmosphere, add a solution of 5.4 g (0.02 mole) 2-(4-hydroxyphenoxy)-3-methylquinoxaline in 30 cc dimethylformamide to 0.9 g (0.02 mole) 57% sodium hydride in 20 cc dimethylformamide at about 20° C. When the evolution of hydrogen ceases, add 3.9 g (0.02 mole) methyl 4-bromo-2-pentenoate. Heat the reaction mixture at approximately 80° C. until the reaction is complete. Pour the reaction mixture into water and extract with ether. Combine the ethereal extracts and dry over magnesium sulfate. Removal of the ether gives the desired product.

후처리

  1. extractionextract with ether
  2. dry with materialdry over magnesium sulfate
  3. customRemoval of the ether

출처 및 근거

ORD 기록
ord-aa9f6b8071fc48d085f88192195dc687
출처 데이터셋
uspto-grants-1986_09
특허 번호
US04609396

연결된 노트

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