Hydroxyamine hydrochloride → 6-Methyl-1H-indole-3-carbaldehyde oxime

HRID 646063

반응식

HRID 646063 반응식
[CH3:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH:11]=O)=[CH:7][NH:8]2)=[CH:4][CH:3]=1.Cl.[NH2:14][OH:15].C([O-])(=O)C.[Na+]>C(O)C>[CH3:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH:11]=[N:14][OH:15])=[CH:7][NH:8]2)=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 47779026-Methylindole-3-carboxaldehyde

생성물 1

HCID 1363955696-Methyl-1H-indole-3-carbaldehyde oxime수율 91.4%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 6-methyl-1H-indole-3-carbaldehyde (0.96 g, Lit. 5) in ethanol (30 ml) was added at 22° C. hydroxylamine hydrochloride (0.46 g) and sodium acetate (0.54 g) and the mixture was stirred for 3 h. The mixture was evaporated and the residue triturated with water and dichloromethane/n-heptane (1:1) and dried to give 6-methyl-1H-indole-3-carbaldehyde oxime (0.96 g) as a pink solid. MS: 175.3 ([M+H]+).

후처리

  1. customThe mixture was evaporated
  2. customthe residue triturated with water and dichloromethane/n-heptane (1:1)
  3. customdried

출처 및 근거

ORD 기록
ord-b90193e147e7431d8791c9d28d336624
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07705034B2

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