Pyrrole-2-carboxaldehyde → HCID 11564718, 화합물

HRID 646185

반응식

HRID 646185 반응식
[NH:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]=O.[CH3:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[CH2:15][C:16]#[N:17]>C(O)C>[CH3:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1/[C:15](=[CH:6]/[C:2]1[NH:1][CH:5]=[CH:4][CH:3]=1)/[C:16]#[N:17]

참가 물질

4

반응물 2

HCID 13854Pyrrole-2-carboxaldehydeHCID 311552-(o-Tolyl)acetonitrile

생성물 1

HCID 11564718HCID 11564718, 화합물수율 30.5%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
90 °C

실험 절차

A thick walled tube was charged with 1H-pyrrole-2-carbaldehyde (2.0 g, 21.0 mmol), 2-methylphenylacetonitrile (2.5 g, 18.9 mmol, 0.9 equivalents), ethanol (75 ml), and 40% aqueous Triton B (4.0 ml, 3.3 mmol). The tube was sealed and heated to 90° C. for 4 days. Removal of the solvent, followed by chromatography on silica gel using dichloromethane/petroleum spirits (20:80) as eluant afforded a yellow solid (1.2 g). This is Compound 16 in Table 8.

후처리

  1. customThe tube was sealed
  2. customRemoval of the solvent

출처 및 근거

ORD 기록
ord-f0f6894a5e0e45489252798d02e21b8b
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07705038B2

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