Resorcinol → 1-(2,4-Dihydroxyphenyl)-2-methylpropan-1-one

HRID 646509노트

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HRID 646509 반응식
[C:1]1([CH:8]=[CH:7][CH:6]=[C:4]([OH:5])[CH:3]=1)[OH:2].B(F)(F)F.CCOCC.[C:18](O)(=[O:22])[CH:19]([CH3:21])[CH3:20].CC([O-])=O.[Na+]>>[OH:2][C:1]1[CH:3]=[C:4]([OH:5])[CH:6]=[CH:7][C:8]=1[C:18](=[O:22])[CH:19]([CH3:21])[CH3:20]

참가 물질

5

반응물 4

HCID 5054ResorcinolHCID 6590Isobutyric AcidHCID 8000Boron trifluoride etherateHCID 517045Sodium Acetate

생성물 1

HCID 159157311-(2,4-Dihydroxyphenyl)-2-methylpropan-1-one

반응 조건

온도
90 °C

실험 절차

Resorcinol (1 eq) was taken up in BF3.OEt2 (6 eq) and isobutyric acid (1 eq) added. The solution was heated for 1.5 hours at 90° C. than allowed to cool to room temperature. The solution was added drop wise to 10% NaOAc (aq) and allowed to stand for 4 hours, before being extracted in to EtOAc. The organic phases were combined and washed with sat. NaHCO3 (aq), then dried over magnesium sulfate, filtered and concentrated in vacuo to give 1-(2,4-dihydroxy-phenyl)-2-methyl-propan-1-one as a red oil which was used without additional purification

후처리

  1. temperatureto cool to room temperature
  2. extractionbefore being extracted in to EtOAc
  3. washwashed with sat. NaHCO3 (aq)
  4. dry with materialdried over magnesium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-629a491d9c504328bf566b1815872bd6
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07705027B2

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