Triphenylphosphine → HCID 178508341, 화합물

HRID 646731노트

반응식

HRID 646731 반응식
[C:1]1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[NH2:20][C:21]1[N:22]=[CH:23][C:24]([C:38]2[CH:39]=[C:40]([CH2:44]O)[CH:41]=[CH:42][CH:43]=2)=[N:25][C:26]=1[C:27]1[NH:31][C:30]([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)=[N:29][N:28]=1.[C@@H:46]1([NH:55][S:56]([C:59]2[CH:64]=[CH:63][C:62]([N+:65]([O-:67])=[O:66])=[CH:61][C:60]=2[N+:68]([O-:70])=[O:69])(=[O:58])=[O:57])[C:54]2[C:49](=[CH:50][CH:51]=[CH:52][CH:53]=2)[CH2:48][CH2:47]1.N(C(OCC)=O)=NC(OCC)=O>C1COCC1.C(OCC)(=O)C>[NH2:20][C:21]1[N:22]=[CH:23][C:24]([C:38]2[CH:39]=[C:40]([CH:41]=[CH:42][CH:43]=2)[CH2:44][N:55]([C@@H:46]2[C:54]3[C:49](=[CH:50][CH:51]=[CH:52][CH:53]=3)[CH2:48][CH2:47]2)[S:56]([C:59]2[CH:64]=[CH:63][C:62]([N+:65]([O-:67])=[O:66])=[CH:61][C:60]=2[N+:68]([O-:70])=[O:69])(=[O:58])=[O:57])=[N:25][C:26]=1[C:27]1[NH:31][C:30]([CH2:32][C:33]2[CH:1]=[CH:37][CH:36]=[CH:35][CH:34]=2)=[N:29][N:28]=1

참가 물질

7

반응물 4

HCID 11776TriphenylphosphineHCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 86607845N-[(1S)-2,3-dihydro-1H-inden-1-yl]-2,4-dinitrobenzen sulfonamideHCID 178508343HCID 178508343, 화합물

생성물 1

HCID 178508341HCID 178508341, 화합물

시약·촉매·용매 2

HCID 8028Tetrahydrofuran용매HCID 8857Ethyl Acetate용매

실험 절차

Triphenylphosphine (47 mg, 0.17 mmol) was added to a stirred solution of {3-[5-amino-6-(5-phenyl-4H-1,2,4-triazol-3-yl) pyrazine-2-yl]phenyl}methanol (50 mg, 0.14 mmol) and N-[(1S)-2,3-dihydro-1H-inden-1-yl]-2,4-dinitrobenzen sulfonamide (60 mg, 0.16 mmol) in THF. Diethyl azodicarboxylate (31 mg, 0.17 mmol) was then added and mixture was stirred at ambient temperature 4 h. Ethyl acetate (20 mL) was added, and the organic layer was washed with saturated aqueous sodium chloride, and then dried (Na2SO4). Filtration and concentration followed by chromatography on silica gel afforded the title compound: MS (EI) for C35H29N9O6S: 704 (MH+).

후처리

  1. washthe organic layer was washed with saturated aqueous sodium chloride
  2. dry with materialdried (Na2SO4)
  3. filtrationFiltration and concentration

출처 및 근거

ORD 기록
ord-0dfe80fcffe04a9cacdd4cee45d0e875
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07704995B2

반응 노트

불러오는 중…