3-(1-oxo-4-ethoxycarbonylbutyl)-N-(3-pyridyl)indole → 3-(1-oxo-4-carboxybutyl)-N-(3-pyridyl)-indole

HRID 64679노트

반응식

HRID 64679 반응식
[O:1]=[C:2]([C:11]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:13]([C:20]2[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=2)[CH:12]=1)[CH2:3][CH2:4][CH2:5][C:6]([O:8]CC)=[O:7]>[OH-].[Na+]>[O:1]=[C:2]([C:11]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:13]([C:20]2[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=2)[CH:12]=1)[CH2:3][CH2:4][CH2:5][C:6]([OH:8])=[O:7]

참가 물질

3

반응물 1

HCID 136726963-(1-oxo-4-ethoxycarbonylbutyl)-N-(3-pyridyl)indole

생성물 1

HCID 136726973-(1-oxo-4-carboxybutyl)-N-(3-pyridyl)-indole

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매

실험 절차

A mixture of 15.0 of 3-(1-oxo-4-ethoxycarbonylbutyl)-N-(3-pyridyl)indole, 100 ml of 0.5N sodium hydroxide is heated under reflux for 16 hours. The solution is acidified to pH of about 6 with hydrochloric and extracted with methylene chloride. The methylene chloride extract is dried over sodium sulfate and evaporated to dryness to give 3-(1-oxo-4-carboxybutyl)-N-(3-pyridyl)-indole, melting point 177°-178°.

후처리

  1. temperatureis heated
  2. temperatureunder reflux for 16 hours
  3. extractionextracted with methylene chloride
  4. extractionThe methylene chloride extract
  5. dry with materialis dried over sodium sulfate
  6. customevaporated to dryness

출처 및 근거

ORD 기록
ord-bac6c13fde434d098a681ccd1fde0d81
출처 데이터셋
uspto-grants-1986_09
특허 번호
US04609733

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