Triethylamine → Methyl 3-ethoxy-2-(ethoxyimino)-3-iminopropanoate

HRID 647113

반응식

HRID 647113 반응식
F[B-](F)(F)F.[CH2:6]([O+](CC)CC)[CH3:7].[F-].[C:14]([C:17](=[N:22][O:23][CH2:24][CH3:25])[C:18]([O:20][CH3:21])=[O:19])(=[O:16])[NH2:15].C(N(CC)CC)C>C(Cl)Cl.O>[NH:15]=[C:14]([O:16][CH2:6][CH3:7])[C:17](=[N:22][O:23][CH2:24][CH3:25])[C:18]([O:20][CH3:21])=[O:19]

참가 물질

7

반응물 4

HCID 8471TriethylamineHCID 28179Fluoride IonHCID 2723982Triethyloxonium tetrafluoroborateHCID 53690437Methyl 3-amino-2-(ethoxyimino)-3-oxopropanoate

생성물 1

HCID 53663360Methyl 3-ethoxy-2-(ethoxyimino)-3-iminopropanoate

시약·촉매·용매 2

HCID 962Water용매HCID 6344Dichloromethane용매

실험 절차

To a solution of Meerwein reagent (triethyloxonium tetrafluoroborate) {prepared from bron fluoride etherate (2.84 g) by a method of Org. Syn., 46, 113 (1966)} in methylene chloride (30 ml) was added methyl 2-carbamoyl-2-ethoxyiminoacetate (syn isomer, 2.6 g) and the mixture was stirred for 18 hours at room temperature. The reaction mixture was cooled in an ice-bath and triethylamine (3 g) was added thereto, followed by an addition of water (20 ml). The organic layer was separated out, dried over magnesium sulfate and evaporated to give crude methyl 3-imino-3-ethoxy-2-ethoxyiminopropionate (syn isomer) (5.0 g) as an oil. ##STR15##

후처리

  1. temperatureThe reaction mixture was cooled in an ice-bath
  2. customThe organic layer was separated out
  3. dry with materialdried over magnesium sulfate
  4. customevaporated

출처 및 근거

ORD 기록
ord-c2c14045175f4522914e930aa28b5372
출처 데이터셋
uspto-grants-1983_10
특허 번호
US04407798

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