Water → 3-(N-n-Heptadecylcarbamoyl)oxypropan-1-ol

HRID 647272노트

반응식

HRID 647272 반응식
[CH2:1]([N:18]=[C:19]=[O:20])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17].O.C(Cl)(Cl)Cl.[CH2:26]([OH:30])[CH2:27][CH2:28][OH:29]>C(Cl)Cl>[CH2:1]([NH:18][C:19]([O:29][CH2:28][CH2:27][CH2:26][OH:30])=[O:20])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17]

참가 물질

6

반응물 4

HCID 962WaterHCID 6212ChloroformHCID 104421,3-PropanediolHCID 135601031-Isocyanatoheptadecane

생성물 1

HCID 135601043-(N-n-Heptadecylcarbamoyl)oxypropan-1-ol수율 47.2%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

In a mixture of 5.7 g of 1,3-propanediol and 30 ml of methylene chloride is dissolved 5.0 g of n-heptadecyl isocyanate and the mixture is stirred at room temperature overnight. To the reaction mixture are added 20 ml each of water and chloroform, and the organic layer is taken and concentrated to dryness. Then, silica gel column chromatography is carried out [eluent:chloroform-water (97:3)] and the eluate is concentrated to dryness. The procedure provides 3.0 g of the above-indicated compound as colorless crystals.

후처리

  1. concentrationconcentrated to dryness
  2. concentrationthe eluate is concentrated to dryness

출처 및 근거

ORD 기록
ord-0eb66856d89f445ca8a74959e6e21846
출처 데이터셋
uspto-grants-1983_10
특허 번호
US04408052

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