HCID 12926609, 화합물 → SR 57227A

HRID 647516노트

반응식

HRID 647516 반응식
C([NH:4][CH:5]1[CH2:10][CH2:9][N:8]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([Cl:17])[N:12]=2)[CH2:7][CH2:6]1)(=O)C>Cl>[NH2:4][CH:5]1[CH2:10][CH2:9][N:8]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([Cl:17])[N:12]=2)[CH2:7][CH2:6]1

참가 물질

3

반응물 1

HCID 12926609HCID 12926609, 화합물

생성물 1

HCID 131747SR 57227A수율 72%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

A solution of 0.482 mole of 4-acetamido-1-(6-chloro-2-pyridyl)piperidine in 610 ml of 6 N hydrochloric acid is heated at reflux for 8 hours, then the reaction mixture is cooled and concentrated under reduced pressure. The residue is treated with 4 N sodium hydroxide up to a clearly basic pH and the oil which separates is extracted with diethyl ether. The organic phase is washed with water, dried over anhydrous sodium sulfate and evaporated to dryness. The oily residue is crystallised by diisopropylic ether. 4-amino-1-(6-chloro-2-pyridyl)piperidine is thus obtained; m.p. 36° to 38° C.

후처리

  1. temperatureat reflux for 8 hours
  2. temperaturethe reaction mixture is cooled
  3. concentrationconcentrated under reduced pressure
  4. additionThe residue is treated with 4 N sodium hydroxide up to a clearly basic pH
  5. extractionthe oil which separates is extracted with diethyl ether
  6. washThe organic phase is washed with water
  7. dry with materialdried over anhydrous sodium sulfate
  8. customevaporated to dryness
  9. customThe oily residue is crystallised by diisopropylic ether

출처 및 근거

ORD 기록
ord-c6372d8c214444b3acdbfac197ae593c
출처 데이터셋
uspto-grants-1983_10
특허 번호
US04409228

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