Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Aminopropionitrile → 3-[N-{2-nitro-5-(2-chloro-4-isopropylsulphonylphenoxy)phenyl}amino]propionitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Aminopropionitrile | HCID 1647 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Fumarate | HCID 5460307 | — |
| 반응물 | 2-Chloro-4-isopropylsulphonyl-(3,4-dinitrophenoxy)benzene | HCID 20237345 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 3-[N-{2-nitro-5-(2-chloro-4-isopropylsulphonylphenoxy)phenyl}amino]propionitrile | HCID 20237333 | 70.9% |
반응 단계
A solution of 4.0 g of 2-chloro-4-isopropylsulphonyl-(3,4-dinitrophenoxy)benzene and 3.85 g of 3-aminopropionitrile. 0.5 fumarate in 100 ml of acetonitrile, to which 4.1 g of potassium carbonate was added, was refluxed for 6 hours. After evaporation the residue was dissolved in methylenechloride an extracted with water. After washing with water the organic layer was filtered and reduced. Recrystallisation from methanol yielded 3.0 g of the desired product; m.p. 140° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04609753 |
| 출처 데이터셋 | uspto-grants-1986_09 |
| ORD ID | ord-59d1622462e9450283df71a7ce662383 |
| 출처 메모 | uspto-grants-1986_09 |