Hydrochloric Acid → (2-Ethyl-1,6-dioxaspiro[4.5]decan-2-yl)methanol

HRID 647751노트

반응식

HRID 647751 반응식
[CH2:1]([C:3]1([O:13][CH2:12]1)[CH2:4][CH2:5][C:6]1[O:11][CH2:10][CH2:9][CH2:8][CH:7]=1)[CH3:2].Cl.C([O:17]CC)C>O1CCCC1>[CH2:1]([C:3]1([CH2:12][OH:17])[CH2:4][CH2:5][C:6]2([CH2:7][CH2:8][CH2:9][CH2:10][O:11]2)[O:13]1)[CH3:2]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 132371796-[2-(2-Ethyloxiran-2-yl)ethyl]-3,4-dihydro-2H-pyran

생성물 1

HCID 13237167(2-Ethyl-1,6-dioxaspiro[4.5]decan-2-yl)methanol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To 5.5 g of 6-(3-ethyl-(3,4-epoxybutyl))-3,4-dihydro-2H-pyran was added a solution of 2 ml of 10% hydrochloric acid in 25 ml of tetrahydrofuran. The reaction mixture was stirred under nitrogen for five days and then poured into 150 ml of diethyl ether. The resulting solution was washed twice with 50 ml of saturated sodium bicarbonate solution, and dried, and the solvent was removed under high vacuum to yield 6 g of the desired product as a dark brown oil.

후처리

  1. washThe resulting solution was washed twice with 50 ml of saturated sodium bicarbonate solution
  2. customdried
  3. customthe solvent was removed under high vacuum

출처 및 근거

ORD 기록
ord-cadce283ebfd4e47ad7d3e5fa611f4d4
출처 데이터셋
uspto-grants-1983_10
특허 번호
US04410354

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