Thionyl Chloride → Methyl 2-(dimethylamino)-N-[[[[[(diethoxyphosphinothioyl)isopropylamino]sulfinyl]methylamino]carbonyl]oxy]-2-oxoethanimidothioate

HRID 647796

반응식

HRID 647796 반응식
[CH3:1][N:2]([CH3:14])[C:3](=[O:13])[C:4]([S:11][CH3:12])=[N:5][O:6][C:7]([NH:9][CH3:10])=[O:8].[S:15](Cl)(Cl)=[O:16].[CH:19]([NH:22][P:23](=[S:30])([O:27][CH2:28][CH3:29])[O:24][CH2:25][CH3:26])([CH3:21])[CH3:20]>N1C=CC=CC=1>[CH3:14][N:2]([CH3:1])[C:3](=[O:13])[C:4]([S:11][CH3:12])=[N:5][O:6][C:7]([NH:9][CH2:10][S:15]([N:22]([P:23]([O:24][CH2:25][CH3:26])([O:27][CH2:28][CH3:29])=[S:30])[CH:19]([CH3:21])[CH3:20])=[O:16])=[O:8]

참가 물질

5

반응물 3

HCID 24386Thionyl ChlorideHCID 31657OxamylHCID 778771Phosphoramidothioic acid, (1-methylethyl)-, O,O-diethyl ester

생성물 1

HCID 86739081Methyl 2-(dimethylamino)-N-[[[[[(diethoxyphosphinothioyl)isopropylamino]sulfinyl]methylamino]carbonyl]oxy]-2-oxoethanimidothioate

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

Methyl 2-(dimethylamino)-N-[[[[[(diethoxyphosphinothioyl)isopropylamino]sulfinyl]methylamino]carbonyl]oxy]-2-oxoethanimidothioate was prepared by the procedure employed in Example 21, by reacting methyl 2-(dimethylamino)-N-[[(methylamino)carbonyl]oxy]-2-oxoethanimidothioate (3.29 g, 0.015 mole), thionyl chloride (1.79 g, 0.015 mole), and O,O-diethyl isopropylphosphoramidothioate (3.17 g, 0.015 mole) in pyridine (10 ml). Column chromatography afforded 2.6 g of an oil of the formula below, nD24 1.5211 ##STR42##

출처 및 근거

ORD 기록
ord-bc98f0a394bd4856a913cc31935e8b76
출처 데이터셋
uspto-grants-1983_10
특허 번호
US04410518

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