Hydrazine hydrate (1:1) → 6-[p-(1-chlorocyclopropylcarbonylamino)-phenyl]-4,5-dihydro-3(2H)-pyridazinone

HRID 647809노트

반응식

HRID 647809 반응식
[Cl:1][C:2]1([C:5]([NH:7][C:8]2[CH:20]=[CH:19][C:11]([C:12]([CH2:14][CH2:15][C:16](O)=[O:17])=O)=[CH:10][CH:9]=2)=[O:6])[CH2:4][CH2:3]1.O.[NH2:22][NH2:23]>C(O)C>[Cl:1][C:2]1([C:5]([NH:7][C:8]2[CH:20]=[CH:19][C:11]([C:12]3[CH2:14][CH2:15][C:16](=[O:17])[NH:22][N:23]=3)=[CH:10][CH:9]=2)=[O:6])[CH2:4][CH2:3]1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 204833713-[p-(1-Chlorocyclopropylcarbonylamino)-benzoyl]-propionic acid

생성물 1

HCID 128073356-[p-(1-chlorocyclopropylcarbonylamino)-phenyl]-4,5-dihydro-3(2H)-pyridazinone수율 92.1%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

2.75 g (9.3 millimoles) of 3-[p-(1-chlorocyclopropylcarbonylamino)-benzoyl]-propionic acid, 0.47 g (9.4 millimoles) of hydrazine hydrate and 20 ml of ethanol are refluxed for 6 hours. The product is filtered off at 10° C., washed with ethanol and dried under reduced pressure at 50° C., giving 2.5 g (92% of theory) of 6-[p-(1-chlorocyclopropylcarbonylamino)-phenyl]-4,5-dihydro-3(2H)-pyridazinone as colorless crystals (identical with the compound from Example 7).

후처리

  1. filtrationThe product is filtered off at 10° C.
  2. washwashed with ethanol
  3. customdried under reduced pressure at 50° C.

출처 및 근거

ORD 기록
ord-93cf9e568d4d4d569ec87f1bc7209c96
출처 데이터셋
uspto-grants-1983_10
특허 번호
US04410529

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