Hydrochloric Acid → 2-Amino-4-(2-nitrophenyl)butyric acid hydrochloride

HRID 647848노트

반응식

HRID 647848 반응식
C([NH:4][C:5]([CH2:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[N+:24]([O-:26])=[O:25])(C(OCC)=O)[C:6]([O:8]CC)=[O:7])(=O)C.[ClH:27]>>[ClH:27].[NH2:4][CH:5]([CH2:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[N+:24]([O-:26])=[O:25])[C:6]([OH:8])=[O:7]

참가 물질

3

반응물 2

HCID 313Hydrochloric AcidHCID 20244794Diethyl acetamido[2-(2-nitrophenyl)ethyl]propanedioate

생성물 1

HCID 132435492-Amino-4-(2-nitrophenyl)butyric acid hydrochloride

실험 절차

A solution of diethyl 2-acetamido-2-(o-nitrophenethyl)malonate (80 g) in 3N hydrochloric acid (900 ml) was refluxed for 12 hours. The solution was cooled and extracted with ethyl acetate (200 ml). The aqueous solution was filtered, and evaporated to dryness under reduced pressure. The residue was recrystallized from ethanol/ether to give 2-amino-4-(2-nitrophenyl)butyric acid hydrochloride, m.p. 219°-221° (dec).

후처리

  1. temperatureThe solution was cooled
  2. extractionextracted with ethyl acetate (200 ml)
  3. filtrationThe aqueous solution was filtered
  4. customevaporated to dryness under reduced pressure
  5. customThe residue was recrystallized from ethanol/ether

출처 및 근거

ORD 기록
ord-63a627f38ce24989b7b9d8eb71d49132
출처 데이터셋
uspto-grants-1983_10
특허 번호
US04410520

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