Water → 5-(2-Formyl-3-hydroxyphenoxy)pentanoic acid

HRID 647904

반응식

HRID 647904 반응식
[CH:1]([C:3]1[C:16]([OH:17])=[C:15](C(O)=O)[CH:14]=[CH:13][C:4]=1[O:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11])=[O:2].O.[OH-].[Na+]>O1CCOCC1>[CH:1]([C:3]1[C:16]([OH:17])=[CH:15][CH:14]=[CH:13][C:4]=1[O:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11])=[O:2]

참가 물질

5

반응물 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 204843435-(2-Formyl-3-hydroxy-4-carboxyphenoxy)pentanoic acid

생성물 1

HCID 721625-(2-Formyl-3-hydroxyphenoxy)pentanoic acid

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

5-(2-Formyl-3-hydroxy-4-carboxyphenoxy)pentanoic acid (0.2 g, 0.0007 M), acidic alumina (0.1 g), water (10 ml) and dioxane (3 ml) were left at reflux for 4 days. The reaction mixture was cooled, and made alkaline by the addition of sodium hydroxide. The reaction mixture was filtered and the filtrate acidified with concentrated hydrochloric acid. The resulting precipitate was filtered and washed with a little water, then dried in a desiccator over phosphorus pentoxide to give the title compound as a pale-yellow solid, homogeneous on thin layer chromatography.

후처리

  1. temperatureat reflux for 4 days
  2. temperatureThe reaction mixture was cooled
  3. filtrationThe reaction mixture was filtered
  4. filtrationThe resulting precipitate was filtered
  5. washwashed with a little water
  6. dry with materialdried in a desiccator over phosphorus pentoxide

출처 및 근거

ORD 기록
ord-83a0171f6a7a4a3a900cc9b5587a8149
출처 데이터셋
uspto-grants-1983_10
특허 번호
US04410537

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