Allyl Alcohol → HCID 20482369, 화합물

HRID 648183노트

반응식

HRID 648183 반응식
[H-].[Na+].[CH2:3]([OH:6])[CH:4]=[CH2:5].[H][H].Br[C:10]1[S:11][C:12]([C:15](=[O:19])[N:16]([CH3:18])[CH3:17])=[CH:13][N:14]=1>CN(C)C=O.O>[CH2:3]([O:6][C:10]1[S:11][C:12]([C:15](=[O:19])[N:16]([CH3:18])[CH3:17])=[CH:13][N:14]=1)[CH:4]=[CH2:5]

참가 물질

7

반응물 4

HCID 7858Allyl AlcoholHCID 24758Sodium hydrideHCID 204823682-bromo-N,N-dimethyl-1,3-thiazole-5-carboxamideHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 20482369HCID 20482369, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

To a stirred suspension of 0.5 g (10 mmol) of sodium hydride in 5 ml of dry N,N-di-methylformamide under N2, there can be added 0.6 g (10 mmol) of sieve-dried allyl alcohol. After hydrogen evolution ceases, the stirred solution can be treated with 2-bromo-5-(N,N-dimethylcarbamoyl)thiazole (2.35 g, 10.0 mmole). The mixture can then be stirred at 40° under N2 for 18 hours, diluted with four volumes of water and extracted with ether. The ether extracts can be washed with water, dried (Na2SO4), filtered and concentrated in vacuo to give an oil which can then be distilled to give pure title compound.

후처리

  1. extractionextracted with ether
  2. washThe ether extracts can be washed with water
  3. dry with materialdried (Na2SO4)
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo
  6. customto give an oil which
  7. distillationcan then be distilled

출처 및 근거

ORD 기록
ord-fe7237d345e04ac1b1577aef2ef9156c
출처 데이터셋
uspto-grants-1983_10
특허 번호
US04411899

반응 노트

불러오는 중…