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1-Butanol → 1-[4-[4-(4-Methoxyphenyl)-1-piperazinyl]phenyl]-3-methyl-2-imidazolidinone

HRID 648486
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HRID 648486 반응식
Cl[CH2:2][CH2:3][N:4]([CH2:13][CH2:14]Cl)[C:5]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][CH:6]=1.[NH2:16][C:17]1[CH:22]=[CH:21][C:20]([N:23]2[CH2:27][CH2:26][N:25]([CH3:28])[C:24]2=[O:29])=[CH:19][CH:18]=1.C(=O)([O-])O.[Na+].C(O)CCC>O>[CH3:12][O:11][C:8]1[CH:9]=[CH:10][C:5]([N:4]2[CH2:13][CH2:14][N:16]([C:17]3[CH:18]=[CH:19][C:20]([N:23]4[CH2:27][CH2:26][N:25]([CH3:28])[C:24]4=[O:29])=[CH:21][CH:22]=3)[CH2:2][CH2:3]2)=[CH:6][CH:7]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 2631-ButanolHCID 15064N,N-Bis(2-chloroethyl)-4-methoxybenzenamineHCID 516892Sodium BicarbonateHCID 223464461-(4-Aminophenyl)-3-methylimidazolidin-2-one

생성물 1

HCID 137323671-[4-[4-(4-Methoxyphenyl)-1-piperazinyl]phenyl]-3-methyl-2-imidazolidinone수율 73%

시약·촉매·용매 1

HCID 962
Water
용매

실험 절차

A mixture of 16.5 parts of N,N-bis(2-chloroethyl)-4-methoxybenzenamine, 12.5 parts of 1-(4-aminophenyl)-3-methyl-2-imidazolidinone, 11 parts of sodium hydrogen carbonate and 240 parts of 1-butanol was stirred and refluxed for 24 hours. After cooling, 100 parts of water were added and the whole was stirred. The precipitated product was filtered off, washed with water and with 1-butanol and dried, yielding 17.5 parts (73%) of 1-[4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl]-3-methyl-2-imidazolidinone; mp. 240.9°-241.0° C. (28).

후처리

  1. temperaturerefluxed for 24 hours
  2. temperatureAfter cooling
  3. stirringthe whole was stirred
  4. filtrationThe precipitated product was filtered off
  5. washwashed with water and with 1-butanol
  6. customdried

출처 및 근거

ORD 기록
ord-eb8fd28dbd1b4b2a856282f00658a665
출처 데이터셋
uspto-grants-1988_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04735942

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