Water → 2-Chloro-6-nitro-3-pyrrolidinobenzonitrile

HRID 64861

반응식

HRID 64861 반응식
[Cl:1][C:2]1[C:9](Cl)=[CH:8][CH:7]=[C:6]([N+:11]([O-:13])=[O:12])[C:3]=1[C:4]#[N:5].[NH:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1.O>CN(C)C=O>[Cl:1][C:2]1[C:9]([N:14]2[CH2:18][CH2:17][CH2:16][CH2:15]2)=[CH:8][CH:7]=[C:6]([N+:11]([O-:13])=[O:12])[C:3]=1[C:4]#[N:5]

참가 물질

5

반응물 3

HCID 962WaterHCID 31268PyrrolidineHCID 27360202,3-Dichloro-6-nitrobenzonitrile

생성물 1

HCID 134992682-Chloro-6-nitro-3-pyrrolidinobenzonitrile수율 88.2%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

13.0 g of 2,3-dichloro-6-nitrobenzonitrile was dissolved in 50 ml of dimethylformamide, and 11.0 g of pyrrolidine was added to the solution, followed by stirring while externally cooling because of heat generation. After continuing the stirring for 30 minutes, the reaction mixture was poured into water. The precipitate thus formed was filtered, washed with water and then with methanol to obtain 13.3 g of 2-chloro-6-nitro-3-pyrrolidinobenzonitrile (melting point: 170°-173° C.).

후처리

  1. temperaturewhile externally cooling because of heat generation
  2. customstirring for 30 minutes
  3. customThe precipitate thus formed
  4. filtrationwas filtered
  5. washwashed with water

출처 및 근거

ORD 기록
ord-25bd0f96e9344708b7d10565fea58a47
출처 데이터셋
uspto-grants-1986_09
특허 번호
US04610987

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