4-Phenylbutyric Acid → Cyclohexanebutanoic acid

HRID 648623

반응식

HRID 648623 반응식
[C:1]1([CH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H][H]>C(O)(=O)C.[Pt]=O>[CH:1]1([CH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

5

반응물 2

HCID 47754-Phenylbutyric AcidHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 75200Cyclohexanebutanoic acid수율 77%

시약·촉매·용매 2

HCID 82844Platinum oxide (PtO)촉매HCID 176Acetic Acid용매

실험 절차

4-Phenylbutanoic acid prepared as described in Example 56, Part A was dissolved in glacial acetic acid (25 ml). Platinum oxide (0.1 g) was added and the solution was hydrogenated in the Paar shaker at up to 55 p.s.i. until hydrogen uptake ceased (6.5 hours). The catalyst was removed by filtration and the acetic acid was removed in vacuo. The product crystallized and was recrystallized from Et2O (20 ml) to give title compound (1.18 g, 77%), m.p. 85°-88° C.

후처리

  1. custom(6.5 hours)
  2. customThe catalyst was removed by filtration
  3. customthe acetic acid was removed in vacuo
  4. customThe product crystallized
  5. customwas recrystallized from Et2O (20 ml)

출처 및 근거

ORD 기록
ord-ae9037d73c6549bfa34638ad5ccece91
출처 데이터셋
uspto-grants-1988_04
특허 번호
US04735962

연결된 노트

불러오는 중…