Benzoyl chloride → HCID 20145253, 화합물

HRID 648641노트

반응식

HRID 648641 반응식
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:10][C:11]1[CH:12]=[CH:13][C:14]([N:32]2[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]2)=[C:15]([CH:17]([CH:19]([C:29]([NH2:31])=[O:30])[C:20]2[CH:28]=[CH:27][C:23]([C:24]([OH:26])=[O:25])=[CH:22][CH:21]=2)[CH3:18])[CH:16]=1.C(N(CC)CC)C>CN(C)C=O>[C:1]([NH:10][C:11]1[CH:12]=[CH:13][C:14]([N:32]2[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]2)=[C:15]([CH:17]([CH:19]([C:29]([NH2:31])=[O:30])[C:20]2[CH:28]=[CH:27][C:23]([C:24]([OH:26])=[O:25])=[CH:22][CH:21]=2)[CH3:18])[CH:16]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 7412Benzoyl chlorideHCID 8471TriethylamineHCID 20145241HCID 20145241, 화합물

생성물 1

HCID 20145253HCID 20145253, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

An amount of 0.30 ml (2.62 m mol) of benzoyl chloride was added dropwise to a solution of 1 gm (2.62 m mol) of 4-[(1-(5-amino-2-piperidino-phenyl)-ethyl)-aminocarbonylmethyl]-benzoic acid and of 0.37 ml (2.62 m mol) of triethylamine in 10 ml of anhydrous dimethyl formamide. After stirring for two hours at 20° to 30° C., the reaction mixture was evaporated in vacuo and distributed between water and ethyl acetate. The organic phase was dried, filtered, and evaporated in vacuo. The evaporation residue (1.12 gm) was recrystallized from ethanol by addition of activated charcoal.

후처리

  1. customthe reaction mixture was evaporated in vacuo
  2. customThe organic phase was dried
  3. filtrationfiltered
  4. customevaporated in vacuo
  5. customThe evaporation residue (1.12 gm) was recrystallized from ethanol by addition of activated charcoal

출처 및 근거

ORD 기록
ord-17f02ebd966d463e845530d2aa1aef43
출처 데이터셋
uspto-grants-1988_04
특허 번호
US04735959

반응 노트

불러오는 중…