Phosphorus oxychloride → (6-Chloro-2-pyridinyl)phenylmethanone

반응식

[C:1]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N+:10]=1[O-])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O=P(Cl)(Cl)[Cl:18]>>[C:1]([C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([Cl:18])[N:10]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

반응물 2

HCID 24813Phosphorus oxychloride

HCID 849885(1-Oxido-2-pyridinyl)(phenyl)methanone

생성물 1

HCID 14023163(6-Chloro-2-pyridinyl)phenylmethanone

실험 절차

1.5 g 2-benzoyl-pyridine N-oxide (T. Kato et. al., see reference in Ex. 11) and 3.6 ml POCl3 are refluxed for 25 minutes. The cooled mixture is added to slightly alkaline ice:water, extracted with chloroform, the organic extract dried and solvent removed in vacuo. Yield: 1.1 g of title product, which by thin layer and gas chromatography is identical with that described in Ex. 7.

후처리

additionThe cooled mixture is added to slightly alkaline ice
extractionwater, extracted with chloroform
extractionthe organic extract
customdried
customsolvent removed in vacuo

출처 및 근거

ORD 기록: ord-be00d624542341b28593406c166b47c8
출처 데이터셋: uspto-grants-1988_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04736037

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