2-[(2-chloro-1-oxo-propyl)-amino]-beta-oxo-N-(2-pyridinyl)-3-trifluoromethyl-benzene-propanamide → HCID 178434920, 화합물

HRID 648737노트

반응식

HRID 648737 반응식
Cl[CH:2]([CH3:28])[C:3]([NH:5][C:6]1[C:11]([C:12]([F:15])([F:14])[F:13])=[CH:10][CH:9]=[CH:8][C:7]=1[C:16](=[O:27])[CH2:17][C:18]([NH:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][N:22]=1)=[O:19])=O>CN(C)C1C=CN=CC=1.O1CCCC1>[CH3:28][CH:2]1[C:3]2=[N:5][C:6]3[C:11]([C:12]([F:14])([F:15])[F:13])=[CH:10][CH:9]=[CH:8][C:7]=3[C:16]([OH:27])=[C:17]2[C:18](=[N:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][N:22]=2)[O:19]1

참가 물질

4

반응물 1

HCID 134231002-[(2-chloro-1-oxo-propyl)-amino]-beta-oxo-N-(2-pyridinyl)-3-trifluoromethyl-benzene-propanamide

생성물 1

HCID 178434920HCID 178434920, 화합물수율 115.2%

시약·촉매·용매 2

HCID 142844-(Dimethylamino)pyridine촉매HCID 8028Tetrahydrofuran용매

실험 절차

1.60 g of 4-dimethylamino-pyridine were added to a suspension of 4.5 g of the product of Step A in 90 ml of tetrahydrofuran and the mixture was refluxed for four hours and was evaporated to dryness under reduced pressure. The residue was added to 90 ml of water and the mixture was stirred for 30 minutes and was vacuum filtered. The product was washed with water and dried under reduced pressure at 70° C. to obtain 4.50 g of 1,3-dihydro-3-methyl-1-[(2-pyridinyl)-imino]-5-trifluoromethyl-furo[3,4-b]quinoline-9-ol which was crystallized from absolute ethanol.

후처리

  1. temperaturethe mixture was refluxed for four hours
  2. customwas evaporated to dryness under reduced pressure
  3. additionThe residue was added to 90 ml of water
  4. filtrationfiltered
  5. washThe product was washed with water
  6. customdried under reduced pressure at 70° C.

출처 및 근거

ORD 기록
ord-0452092e013c4fae9c6335baa11ebcc9
출처 데이터셋
uspto-grants-1988_04
특허 번호
US04736033

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