Hydrochloric Acid → Octyl 4-formylbenzoate

HRID 648873노트

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HRID 648873 반응식
[C:1](Cl)(=[O:10])[C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1.[CH2:12]([OH:20])[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19].Cl>C1(C)C=CC=CC=1.N1C=CC=CC=1>[CH2:12]([O:20][C:1]([C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1)=[O:10])[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 9571-OctanolHCID 124246204-Formylbenzoyl chloride

생성물 1

HCID 13404982Octyl 4-formylbenzoate수율 70.7%

시약·촉매·용매 2

HCID 1049Pyridine용매HCID 1140Toluene용매2회

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온도
60 °C

실험 절차

Next, a solution of the above terephthalaldehydic acid chloride (20 g) dissolved in toluene (100 ml) was dropwise added to a solution of 1-octanol (20 g) dissolved in pyridine (150 ml), followed by heating the mixture on a water bath at 60° C. with stirring, allowing to stand overnight, thereafter adding toluene (500 ml), adding 6N hydrochloric acid, separating the liquid layer, washing with an aqueous solution of 2N NaOH, washing with water, drying, distilling off toluene, and further distilling under reduced pressure to obtain p-octyloxycarbonylbenzaldehyde (166°~167° C./4 mmHg) (22 g).

후처리

  1. customseparating the liquid layer
  2. washwashing with an aqueous solution of 2N NaOH
  3. washwashing with water
  4. customdrying
  5. distillationdistilling off toluene
  6. distillationfurther distilling under reduced pressure

출처 및 근거

ORD 기록
ord-6f876f40763e4b7d92bfda9337b5d5e7
출처 데이터셋
uspto-grants-1988_04
특허 번호
US04737313

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