Piperidine → 1-[4-(4-Pyridinylamino)benzoyl]piperidine

반응식

[N:1]1[CH:6]=[CH:5][C:4]([NH:7][C:8]2[CH:16]=[CH:15][C:11]([C:12]([OH:14])=O)=[CH:10][CH:9]=2)=[CH:3][CH:2]=1.[NH:17]1[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1>>[N:1]1[CH:2]=[CH:3][C:4]([NH:7][C:8]2[CH:9]=[CH:10][C:11]([C:12]([N:17]3[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]3)=[O:14])=[CH:15][CH:16]=2)=[CH:5][CH:6]=1

참가 물질

반응물 2

HCID 8082Piperidine

HCID 128960004-(4-Pyridinylamino)benzoic acid

생성물 1

HCID 137124741-[4-(4-Pyridinylamino)benzoyl]piperidine수율 49.5%

실험 절차

1-[4-(4-Pyridinylamino)benzoyl]piperidine was prepared from 4-(4-pyridinylamino)benzoic acid and piperidine according to a procedure analogous to that of Example 48(b), and was obtained in 49.5% yield in the form of a buff powder, m.p. 170°-172° C. when recrystallized from acetonitrile.

후처리

customwas obtained in 49.5% yield in the form of a buff powder, m.p. 170°-172° C. when
customrecrystallized from acetonitrile

출처 및 근거

ORD 기록: ord-64b455ccc0f942d6b583e9d13b6e7b4d
출처 데이터셋: uspto-grants-1986_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04610991

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