4,5-Dihydro-2-(methylthio)thiazole → 3-[2-(2,5-Diketopyrrolidyl)ethyl]-2-methylthiothiazolinium bromide

HRID 649499

반응식

HRID 649499 반응식
[CH3:1][S:2][C:3]1[S:4][CH2:5][CH2:6][N:7]=1.[O:8]=[C:9]1[C:13]([CH2:14][CH2:15][Br:16])=[CH:12][C:11](=[O:17])[N-:10]1>CC(C)=O>[Br-:16].[O:8]=[C:9]1[C:13]([CH2:14][CH2:15][N+:7]2[CH2:6][CH2:5][S:4][C:3]=2[S:2][CH3:1])=[CH:12][C:11](=[O:17])[N-:10]1

참가 물질

4

반응물 2

HCID 883244,5-Dihydro-2-(methylthio)thiazoleHCID 1785159292-(2,5-Diketopyrrolidyl)ethyl bromide

생성물 1

HCID 1785034083-[2-(2,5-Diketopyrrolidyl)ethyl]-2-methylthiothiazolinium bromide수율 66%

시약·촉매·용매 1

HCID 180Acetone용매

반응 조건

온도
130 °C

실험 절차

6.6 g (5×10-2 mols) of 2-methylthiothiazoline and 12.0 g (6×10-2 mols) of 2-(2,5-diketopyrrolidyl)ethyl bromide were heated with stirring for about 3 hours on an oil bath which had been heated to a temperature of 130° C. Thereafter, the reaction system was allowed to cool to room temperature. 50 ml of acetone was added to the reaction system. The resulting precipitate was recovered by decantation. 11.1 g of the desired product was obtained in a 66% yield.

후처리

  1. temperatureto cool to room temperature
  2. customThe resulting precipitate was recovered by decantation

출처 및 근거

ORD 기록
ord-9a83121b071b42cc95706ec848098b96
출처 데이터셋
uspto-grants-1988_04
특허 번호
US04740455

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