Water → 12-Acetyl-5-methoxy-12H-benzo[a]phenothiazine

HRID 64963노트

반응식

HRID 64963 반응식
[CH3:1]C(C)([O-])C.[K+].[C:7]([N:10]1[C:23]2[C:18](=[CH:19][C:20]([OH:28])=[C:21]3[CH:27]=[CH:26][CH:25]=[CH:24][C:22]3=2)[S:17][C:16]2[C:11]1=[CH:12][CH:13]=[CH:14][CH:15]=2)(=[O:9])[CH3:8].CI.O>CN(C=O)C>[C:7]([N:10]1[C:23]2[C:18](=[CH:19][C:20]([O:28][CH3:1])=[C:21]3[CH:27]=[CH:26][CH:25]=[CH:24][C:22]3=2)[S:17][C:16]2[C:11]1=[CH:12][CH:13]=[CH:14][CH:15]=2)(=[O:9])[CH3:8]

참가 물질

6

반응물 4

HCID 962WaterHCID 6328Methyl iodideHCID 1371248512-acetyl-5-hydroxy-12H-benzo[a]phenothiazineHCID 23665647Potassium tert-butoxide

생성물 1

HCID 1371248612-Acetyl-5-methoxy-12H-benzo[a]phenothiazine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Potassium tert-butoxide (800 mg) was added to a solution of 12-acetyl-5-hydroxy-12H-benzo[a]phenothiazine (950 mg) (from Example 3) and methyl iodide (1.5 ml) in DMF (10 ml) and stirred for 15 minutes. Water (80 ml) was added to the reaction mixture and the precipitate was filtered to afford the title compound.

후처리

  1. filtrationthe precipitate was filtered

출처 및 근거

ORD 기록
ord-b694f4419f0c49708dc08209ccec080e
출처 데이터셋
uspto-grants-1986_09
특허 번호
US04611056

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