참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2,4-Difluoronitrobenzene | HCID 67967 | — |
| 반응물 | Ethyl 2-amino-1-benzothiophene-3-carboxylate | HCID 699464 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | Ethyl 2-(5-fluoro-2-nitroanilino)benzo[b]thiophene-3-carboxylate | HCID 18422317 | 44.9% |
반응 단계
Ethyl 2-aminobenzo[b]thiophene-3-carboxylate (69.3 g) and 2,4-difluoronitrobenzene (50 g) were dissolved in dimethyl sulfoxide (550 ml) and heated to 50° C. Thereto was added potassium carbonate (63 g) and the mixture was stirred at 100° C. for 70 min. After cooling, the reaction mixture was allowed to cool to 70° C. and poured into water (2.5 L). The reaction mixture was allowed to stand still, and filtered. The filtrated orange crystals were washed with ethyl acetate to give ethyl 2-(5-fluoro-2-nitroanilino)benzo[b]thiophene-3-carboxylate (50.7 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06271225B1 |
|---|
| 출처 데이터셋 | uspto-grants-2001_08 |
|---|
| ORD ID | ord-81c6691c52ce497596d581f65bc3fe64 |
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| 출처 메모 | uspto-grants-2001_08 |
|---|
