Potassium Carbonate → 1,2,3,4-tetrahydro-8-methyl-[1]benzothieno[2,3-b][1,5]benzothiazepin-12(11H)-one

HRID 649974

반응식

HRID 649974 반응식
Br[C:2]1[S:6][C:5]2[CH2:7][CH2:8][CH2:9][CH2:10][C:4]=2[C:3]=1[C:11]([NH:13][C:14]1[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][C:15]=1[SH:21])=[O:12].C(=O)([O-])[O-].[K+].[K+]>CS(C)=O>[CH3:20][C:17]1[CH:18]=[CH:19][C:14]2[NH:13][C:11](=[O:12])[C:3]3[C:4]4[CH2:10][CH2:9][CH2:8][CH2:7][C:5]=4[S:6][C:2]=3[S:21][C:15]=2[CH:16]=1

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 184223052-bromo-4,5,6,7-tetrahydro-N-(2-mercapto-4-methylphenyl)-benzo[b]thiophene-3-carboxamide

생성물 1

HCID 184222031,2,3,4-tetrahydro-8-methyl-[1]benzothieno[2,3-b][1,5]benzothiazepin-12(11H)-one

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

In the same manner as in Example 18 and using 2-bromo-4,5,6,7-tetrahydro-N-(2-mercapto-4-methylphenyl)-benzo[b]thiophene-3-carboxamide, dimethyl sulfoxide and potassium carbonate, 1,2,3,4-tetrahydro-8-methyl-[1]benzothieno[2,3-b][1,5]benzothiazepin-12(11H)-one (1.87 g) is obtained.

출처 및 근거

ORD 기록
ord-14d41fd5a7614be4985897b272f17122
출처 데이터셋
uspto-grants-2001_08
특허 번호
US06271225B1

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