Thionyl Chloride → 3-Chloro-5-trifluoromethyl-pyridine-2-carbonyl chloride

반응식

[Cl:1][C:2]1[C:3]([C:12]([OH:14])=O)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.S(Cl)([Cl:17])=O>>[Cl:1][C:2]1[C:3]([C:12]([Cl:17])=[O:14])=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1

참가 물질

반응물 2

HCID 24386Thionyl Chloride

HCID 28219083-Chloro-5-(trifluoromethyl)pyridine-2-carboxylic acid

생성물 1

HCID 220135553-Chloro-5-trifluoromethyl-pyridine-2-carbonyl chloride

반응 조건

온도: 25 °C

실험 절차

89.3 g of 3-chloro-5-trifluoromethyl-2-pyridinecarboxylic acid (Example P3) are slowly heated to reflux with 60 ml of thionyl chloride and the mixture is then stirred at that temperature for 4 hours, after which it is cooled to 25° C. and concentrated to dryness in vacuo. Twice, toluene is added and the mixture is again concentrated to dryness. 94.0 g of the desired product are obtained in the form of a yellow residue.

후처리

concentrationconcentrated to dryness in vacuo
additionTwice, toluene is added
concentrationthe mixture is again concentrated to dryness

출처 및 근거

ORD 기록: ord-ad87a9bcb6d84ff58a1cd54544b1e42f
출처 데이터셋: uspto-grants-2001_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06274536B1

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