1,2,3,6-Tetrahydropyridine → 1-(1,3-Benzoxazol-6-ylcarbonyl)-1,2,3,6-tetrahydropyridine

HRID 650540노트

반응식

HRID 650540 반응식
[O:1]1[C:5]2[CH:6]=[C:7]([C:10]([OH:12])=O)[CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1.[NH:13]1[CH2:18][CH:17]=[CH:16][CH2:15][CH2:14]1.C(C1NC=CN=1)(C1NC=CN=1)=O.C(Cl)(=O)C(Cl)=O>>[O:1]1[C:5]2[CH:6]=[C:7]([C:10]([N:13]3[CH2:14][CH:15]=[CH:16][CH2:17][CH2:18]3)=[O:12])[CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1

참가 물질

5

반응물 4

HCID 127501,2,3,6-TetrahydropyridineHCID 65578Oxalyl chlorideHCID 5250894Bis-(1H-imidazol-2-YL)-methanoneHCID 222459381,3-Benzoxazole-6-carboxylic acid

생성물 1

HCID 115359401-(1,3-Benzoxazol-6-ylcarbonyl)-1,2,3,6-tetrahydropyridine

실험 절차

Coupling of 1,3-benzoxazol-6-carboxylic acid with 1,2,3,6-tetrahydropyridine is performed in the same manner as described for the preparation of Invention Compound V through activation with carbonyl diimidazole or by activation with other suitable reagents such as oxalyl chloride. The product can be isolated by the same methods as described for the isolation of Invention Compound V and purified by chromatography on silica gel. EIMS m/z=228 (parent), 146 (base), and 118. 1H NMR δ 2.2 (br, 2), 3.4-4.3 (br m, 4), 5.7-5.95 (br m, 2), 7.52 (dd, 1, J=8.39, 1.49 Hz), 7.64 (d, 1, J=8.41 Hz), 7.87 (d, 1, J=1.32 Hz), and 8.16 ppm (s, 1.).

후처리

  1. customThe product can be isolated by the same methods
  2. custompurified by chromatography on silica gel

출처 및 근거

ORD 기록
ord-4dd09ecd759f40d49e455aeb2ade226c
출처 데이터셋
uspto-grants-2001_08
특허 번호
US06274600B1

반응 노트

불러오는 중…