Triphenylphosphine → HCID 57238973, 화합물

HRID 650583노트

반응식

HRID 650583 반응식
[CH3:1][C:2]1[C:3]([CH:16]([OH:18])[CH3:17])=[CH:4][C:5]2[C:6]([CH3:15])([CH3:14])[CH2:7][CH2:8][C:9]([CH3:13])([CH3:12])[C:10]=2[CH:11]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.N(C(OCC)=O)=NC(OCC)=O.[CH3:50][O:51][C:52](=[O:77])[C@@H:53]([NH:62][C:63]1[CH:68]=[CH:67][CH:66]=[CH:65][C:64]=1[C:69](=[O:76])[C:70]1[CH:75]=[CH:74][CH:73]=[CH:72][CH:71]=1)[CH2:54][C:55]1[CH:60]=[CH:59][C:58](O)=[CH:57][CH:56]=1>C1COCC1>[CH3:50][O:51][C:52](=[O:77])[C@@H:53]([NH:62][C:63]1[CH:68]=[CH:67][CH:66]=[CH:65][C:64]=1[C:69](=[O:76])[C:70]1[CH:75]=[CH:74][CH:73]=[CH:72][CH:71]=1)[CH2:54][C:55]1[CH:56]=[CH:57][C:58]([O:18][CH:16]([C:3]2[C:2]([CH3:1])=[CH:11][C:10]3[C:9]([CH3:13])([CH3:12])[CH2:8][CH2:7][C:6]([CH3:15])([CH3:14])[C:5]=3[CH:4]=2)[CH3:17])=[CH:59][CH:60]=1

참가 물질

6

반응물 4

HCID 11776TriphenylphosphineHCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 49833401-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-ethanolHCID 10667178N-(2-benzoylphenyl)tyrosine methyl ester

생성물 1

HCID 57238973HCID 57238973, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-ethanol (184 mg; 0.75 mmol), triphenylphosphine (268 mg; 1.0 mmol), diethyl azodicarboxylate (0.161 ml; 1.0 mmol) and (2S)-2-((2-benzoylphenyl)amino)-3-(4-hydroxyphenyl)-propionic acid methyl ester (190 mg; 0.5 mmol) in THF (10 ml) was stirred at 0° C. for 1.5 hours and for 16 hours at room temperature. The reaction mixture was evaporated and the residue was purified on column chromatography using methylene chloride as eluent. Yield 118 mg.

후처리

  1. customThe reaction mixture was evaporated
  2. customthe residue was purified on column chromatography

출처 및 근거

ORD 기록
ord-e57f933e14b74c98ab4c86b7bdb57da5
출처 데이터셋
uspto-grants-2001_08
특허 번호
US06274608B1

반응 노트

불러오는 중…