7-Oxodehydroepiandrosterone 3-acetate → 7-Keto-dehydroepiandrosterone

HRID 650699

반응식

HRID 650699 반응식
C([O:4][C@H:5]1[CH2:22][CH2:21][C@@:20]2([CH3:23])[C:7](=[CH:8][C:9](=[O:25])[C@@H:10]3[C@@H:19]2[CH2:18][CH2:17][C@@:15]2([CH3:16])[C@H:11]3[CH2:12][CH2:13][C:14]2=[O:24])[CH2:6]1)(=O)C>CCCCCC.CC(C)=O>[CH3:16][C@@:15]12[C:14](=[O:24])[CH2:13][CH2:12][C@H:11]1[C@@H:10]1[C:9]([CH:8]=[C:7]3[CH2:6][C@@H:5]([OH:4])[CH2:22][CH2:21][C@:20]3([CH3:23])[C@H:19]1[CH2:18][CH2:17]2)=[O:25]

참가 물질

3

반응물 1

HCID 97982297-Oxodehydroepiandrosterone 3-acetate2회

생성물 1

HCID 1933137-Keto-dehydroepiandrosterone

시약·촉매·용매 1

HCID 21880519Acetone hexane용매

실험 절차

The last remains of the product (3) from the mother liquor were obtained by column chromatography of the mother liquor (adsorbed on silica gel) on a small column of silica gel (80-200 mesh) utilizing hexane-acetone (85:15) as eluent. An additional 0.15 gm of 7-oxo-DHEA-Ac (3) was obtained. Total yield 1.75 gm, 56.5% (based on 90% conversion), melting point 185-186° C.

출처 및 근거

ORD 기록
ord-0d502652bd5e4f399ebf5446d026786f
출처 데이터셋
uspto-grants-2001_08
특허 번호
US06274746B1

연결된 노트

불러오는 중…