Hydrochloric Acid → (3R,4R)-4-[4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl]-3-(1,2,3,4-tetrahydro-quinolin-7-ylmethoxy)-piperidine

2.92 g (4.73 mmol) of (3R,4R)-4-[4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl]-3-(1,2,3,4-tetrahydro-quinolin-7-ylmethoxy)-piperidine-1-carboxylic acid tert-butylester were dissolved in 63 ml of abs. methanol, then 63 ml (126 mmol) of hydrochloric acid in methanol (2.0 molar) were added at room temperature. After stirring for 150 minutes at 50° C., the reaction mixture was poured into 150 ml ice-cold 5% sodium hydrogen carbonate solution and the product was extracted five times with 100 ml methylene chloride. The combined organic phases were washed twice with 50 ml distilled water, dried over magnesium sulphate, filtered and concentrated. The crude product (2.9 g, yellow oil) was chromatographed on silica gel with methylene chloride/methanol/28%ammonium hydroxide solution 14:1:0.1 v/v/v to yield 1.90 g (77.7% of theory) of (3R,4R)-4-[4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl]-3-(1,2,3,4-tetrahydro-quinolin-7-ylmethoxy)-piperidine as a slightly yellow resin; MS: 517 (M+H)+.

1. extractionthe product was extracted five times with 100 ml methylene chloride
2. washThe combined organic phases were washed twice with 50 ml
3. distillationdistilled water
4. dry with materialdried over magnesium sulphate
5. filtrationfiltered
6. concentrationconcentrated
7. customThe crude product (2.9 g, yellow oil) was chromatographed on silica gel with methylene chloride/methanol/28%ammonium hydroxide solution 14:1:0.1 v/v/v

ORD 기록

ord-fe4de16d6a5f4cfb9ba860d02fed5a2f

출처 데이터셋

uspto-grants-2001_08

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US06274735B1