Sodium borohydride → 5-Amino-1,2-dimethyl-1,2,3,4-tetrahydroisoquinoline
반응식
[NH2:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][N:6]([CH3:13])[CH:7]2[CH3:12].[BH4-].[Na+]>CO>[NH2:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][N:6]([CH3:13])[CH:7]2[CH3:12]참가 물질
4
실험 절차
To an ice cold solution of 5-amino-1,2-dihydro-1,2-dimethyl isoquinoline (4 g, 23.2 mmol) in methanol (80 ml) was added sodium borohydride (3.51 g, 92.8 mmol) portionwise. The mixture was allowed to stir at room temperature overnight before concentration in vacuo; the residue was then partitioned between water and dichloromethane. The organic layer was dried over sodium sulfate and concentrated in vacuo to afford a light brown oil (4.023 g).
후처리
- customthe residue was then partitioned between water and dichloromethane
- dry with materialThe organic layer was dried over sodium sulfate
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-b4dbccc5d1234b439320822b802a636d
- 출처 데이터셋
- uspto-grants-2001_08
- 특허 번호
- US06277861B1
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