Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylamine, hydrochloride → (s)-(1-Dimethylcarbamoyl-2-thiazol-4-yl-ethyl)-carbamic acid tert-butyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylamine, hydrochloride | HCID 10473 | — |
| 반응물 | 2-((tert-Butoxycarbonyl)amino)-3-(thiazol-4-yl)propanoic acid | HCID 14540322 | — |
| 생성물 | (s)-(1-Dimethylcarbamoyl-2-thiazol-4-yl-ethyl)-carbamic acid tert-butyl ester | HCID 54383962 | — |
반응 단계
Dimethylamine hydrochloride (1.2 mmol) and Boc-L-3-(4-thiazolyl)alanine (1.0 mmol) were coupled according to Procedure A (0-25° C. reaction temperature) and the product purified by chromatography on silica gel eluted with 1-16% ethanol In dichloromethane containing 0.5% ammonium hydroxide. Yield 124 mg, 41%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06277877B1 |
| 출처 데이터셋 | uspto-grants-2001_08 |
| ORD ID | ord-d18d013b226a446b9def77135af71ba0 |
| 출처 메모 | uspto-grants-2001_08 |