Sodium Hydroxide → Sodium alpha-acetylaminocinnamate

HRID 65136

반응식

HRID 65136 반응식
[CH3:1][C:2]1[O:3][C:4](=[O:14])[C:5](=[CH:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:6]=1.[OH-:15].[Na+:16]>O>[C:2]([NH:6][C:5](=[CH:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:4]([O-:3])=[O:14])(=[O:15])[CH3:1].[Na+:16]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 949464-benzylidene-2-methyl-4H-oxazol-5-one2회

생성물 1

HCID 70401301Sodium alpha-acetylaminocinnamate

시약·촉매·용매 1

HCID 962Water용매

실험 절차

In a 100-ml tightly-sealed glass vessel were charged 9.36 g of 2-methyl-4-benzylidene-5-oxazolone and 30 ml of water. Thereafter, 5.3 g of 45% sodium hydroxide solution was added thereto and the resulting mixture was stirred at 40°-45° C. for 2 hours. The 2-methyl-4-benzylidene-5-oxazolone was hydrolyzed to form an aqueous homogeneous solution of sodium α-acetylaminocinnamate. Then, concentrated hydrochloric acid was added to the solution to adjust its pH at 7.2, and subsequently 0.2 g of 5%-palladium-carbon was added thereto. The gas phase in the vessel was purged with nitrogen and then with hydrogen and thereafter the content in the vessel was subjected to catalytic reduction at 40°-45° C. under atmospheric pressure. The reaction time was approximately 90 minutes until hydrogen absorption was completed. During this time period, it was observed that one mole of hydrogen was absorbed to one mole of 2-methyl-4-benzylidene-5-oxazolone.

후처리

  1. customIn a 100-ml tightly-sealed glass vessel

출처 및 근거

ORD 기록
ord-47569ced332e4b0aad263db820dfd2de
출처 데이터셋
uspto-grants-1986_09
특허 번호
US04612388

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