Nor-HN2 → HCID 21708342, 화합물

HRID 651383노트

반응식

HRID 651383 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH2:9])=[CH:5][C:4]=1[C:10]([F:13])([F:12])[F:11].[Cl-].Cl[CH2:16][CH2:17][NH2+:18][CH2:19][CH2:20]Cl>C(O)CCC>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)=[CH:5][C:4]=1[C:10]([F:11])([F:12])[F:13]

참가 물질

4

반응물 2

HCID 13186Nor-HN2HCID 6007055-Amino-2-methoxybenzotrifluoride

생성물 1

HCID 21708342HCID 21708342, 화합물

시약·촉매·용매 1

HCID 2631-Butanol용매

실험 절차

A mixture of 4-methoxy-3-trifluoromethylphenylamine (12 g; 0.0627 mol) and bis(2-chloroethyl) ammonium chloride (11.2 g; 0.0627 mol) in n-butanol (120 ml) was refluxed for 10 hours. The reaction mixture was cooled at room temperature and the crude title compound precipitated as hydrochloride salt overnight. The solid was collected and crystallized from acetone. 7 g; m.p. 244-245° C.

후처리

  1. temperaturewas refluxed for 10 hours
  2. customthe crude title compound precipitated as hydrochloride salt overnight
  3. customThe solid was collected
  4. customcrystallized from acetone

출처 및 근거

ORD 기록
ord-77065d2ad7124cfb88d36133bbc78dd1
출처 데이터셋
uspto-grants-2001_08
특허 번호
US06281218B1

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