Mandelic Acid → Sotalol

HRID 651495

반응식

HRID 651495 반응식
[CH3:1][CH:2]([NH:4][CH2:5][C@@H:6]([OH:18])[C:7]1[CH:12]=[CH:11][C:10]([NH:13][S:14]([CH3:17])(=[O:16])=[O:15])=[CH:9][CH:8]=1)[CH3:3].Cl.C(O)(=O)C(C1C=CC=CC=1)O>>[CH3:3][CH:2]([NH:4][CH2:5][CH:6]([OH:18])[C:7]1[CH:8]=[CH:9][C:10]([NH:13][S:14]([CH3:17])(=[O:16])=[O:15])=[CH:11][CH:12]=1)[CH3:1]

참가 물질

3

반응물 2

HCID 1292Mandelic AcidHCID 165245Dexsotalol hydrochloride

생성물 1

HCID 5253Sotalol

실험 절차

In addition, using chemical method as described by Le Garrec (1987), enriched d-sotalol hydrochloride and l-sotalol hydrochloride were prepared using mandelic acid and subjected to conversion to the base form, chiral separation and reconversion to hydrochloride salt was carried out. The details of these procedures are given below:

후처리

  1. customwere prepared
  2. customsubjected to conversion to the base form, chiral separation and reconversion to hydrochloride salt

출처 및 근거

ORD 기록
ord-b1da450602074d29b7a1aa7f0ca08711
출처 데이터셋
uspto-grants-2001_08
특허 번호
US06281246B1

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