Triethylamine → 4-Methyl-4-(3,5-di-tert-butyl-4-hydroxyphenylthio)-2-pentanone

HRID 65167

반응식

HRID 65167 반응식
[O:1]=[C:2]([CH:4]=[C:5]([CH3:7])[CH3:6])[CH3:3].[C:8]([C:12]1[CH:17]=[C:16]([SH:18])[CH:15]=[C:14]([C:19]([CH3:22])([CH3:21])[CH3:20])[C:13]=1[OH:23])([CH3:11])([CH3:10])[CH3:9].C(N(CC)CC)C>C1(C)C=CC=CC=1>[CH3:6][C:5]([S:18][C:16]1[CH:15]=[C:14]([C:19]([CH3:20])([CH3:21])[CH3:22])[C:13]([OH:23])=[C:12]([C:8]([CH3:11])([CH3:10])[CH3:9])[CH:17]=1)([CH3:7])[CH2:4][C:2](=[O:1])[CH3:3]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 8858Mesityl oxideHCID 703702,6-Di-tert-butyl-4-mercaptophenol

생성물 1

HCID 136435724-Methyl-4-(3,5-di-tert-butyl-4-hydroxyphenylthio)-2-pentanone

시약·촉매·용매 1

HCID 1140Toluene용매2회

실험 절차

8.48 Grams of mesityl oxide (0.084 moles) is added dropwise to a solution of 21.0 grams of 2,6 di-tert-butyl-4-mercaptophenol (0.088 moles) and one gram of triethylamine in 30 ml of toluene. The mixture is heated at 50°-55° C. for six hours. The solvent is then stripped off under vacuum and the residue retained at 60°-65° C. and 0.20 mm. Hg. for two hours. The residue is dissolved in toluene and purified by flash chromatography using silica gel. The product is isolated from solution by distilling off the volatiles under vacuum to a final pressure of 0.10 mm. Hg for five hours.

후처리

  1. temperatureThe mixture is heated at 50°-55° C. for six hours
  2. customretained at 60°-65° C.
  3. custompurified by flash chromatography
  4. customThe product is isolated from solution
  5. distillationby distilling off the volatiles under vacuum to a final pressure of 0.10 mm. Hg for five hours

출처 및 근거

ORD 기록
ord-d4de8aeca9ca45eda5bfc5d0c2ea9d50
출처 데이터셋
uspto-grants-1986_09
특허 번호
US04612341

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