Methyl chloroglyoxylate → HCID 84741837, 화합물

HRID 651757

반응식

HRID 651757 반응식
[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([CH:7]=[CH:8][N:9]2[CH3:12])=[CH:5][CH:4]=1.Cl[C:14](=[O:19])[C:15]([O:17][CH3:18])=[O:16]>CCOCC>[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([C:7]([C:14](=[O:19])[C:15]([O:17][CH3:18])=[O:16])=[CH:8][N:9]2[CH3:12])=[CH:5][CH:4]=1

참가 물질

4

반응물 2

HCID 79846Methyl chloroglyoxylateHCID 47779296-methoxy-1-methyl-1H-indole

생성물 1

HCID 84741837HCID 84741837, 화합물수율 41%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

반응 조건

온도
0 °C

실험 절차

6-Methoxy-1-methyl-1H-indole (1.0 g, 6.19 mmol) was dissolved in ether (10 mL) and cooled to 0° C. Methyl chlorooxoacetate (1.17 mL, 12.4 mmol) was added dropwise. Stirring was continued at 0° C. for 6 h. The mixture was filtered and washed well with ether to give methyl (6-methoxy-1-methyl-1H-indol-3-yl)glyoxylate (621 mg, 41%).

후처리

  1. filtrationThe mixture was filtered
  2. washwashed well with ether

출처 및 근거

ORD 기록
ord-ed957cc20c3948879785331dc05d89d3
출처 데이터셋
uspto-grants-2001_08
특허 번호
US06281356B1

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