Hydrochloric Acid → (2S)-4-(acetyloxy)-2-(2,2,2-trifluoroacetamido)butanoic acid

HRID 651839노트

반응식

HRID 651839 반응식
C(=O)([O-])[O-].[K+].[K+].Cl.[C:8]([O:11][CH2:12][CH2:13][C@@H:14]([C:16]([OH:18])=[O:17])[NH2:15])(=[O:10])[CH3:9].C(OC(=O)C[C:24](=[O:29])[C:25]([F:28])([F:27])[F:26])C.Cl>C(O)C.O>[F:26][C:25]([F:28])([F:27])[C:24]([NH:15][C@H:14]([C:16]([OH:18])=[O:17])[CH2:13][CH2:12][O:11][C:8](=[O:10])[CH3:9])=[O:29]

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 67793Ethyl 4,4,4-trifluoroacetoacetateHCID 45038083O-Acetyl-L-homoserine hydrochloride

생성물 1

HCID 53989376(2S)-4-(acetyloxy)-2-(2,2,2-trifluoroacetamido)butanoic acid수율 45.1%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

7.6 g (55 mol) of potassium carbonate are added to a suspension of 9.9 g (50 mmol) of O-acetyl-L-homoserine hydrochloride and 7.8 g (55 mmol) of trifluoroacetylacetic acid ethyl ester in 200 ml of ethanol, and stirring is carried out for 14 hours. 10.8 g (110 mmol) of 37% hydrochloric acid and 200 ml of water are then added. The product obtained after removal of the ethanol by distillation is filtered off with suction, washed with water and dried. 5.8 g (45%) of N-trifluoroacetyl—O—acetyl-L-homoserine are obtained.

후처리

  1. customThe product obtained
  2. customafter removal of the ethanol
  3. distillationby distillation
  4. filtrationis filtered off with suction
  5. washwashed with water
  6. customdried

출처 및 근거

ORD 기록
ord-ad2d578c277a4e6e8f22133281aeb09c
출처 데이터셋
uspto-grants-2001_08
특허 번호
US06281364B1

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