Trifluoroacetic acid → Ethyl 4-[14-(trimethylsilyl)tetradecylamino]benzoylacetate

HRID 652039

반응식

HRID 652039 반응식
[CH3:1][Si:2]([CH3:40])([CH3:39])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][NH:17][C:18]1[CH:38]=[CH:37][C:21]([C:22]([CH:24](C(OCC)=O)[C:25]([O:27][C:28](C)(C)[CH3:29])=[O:26])=[O:23])=[CH:20][CH:19]=1.FC(F)(F)C(O)=O.[OH-].[K+]>>[CH3:40][Si:2]([CH3:1])([CH3:39])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][NH:17][C:18]1[CH:19]=[CH:20][C:21]([C:22]([CH2:24][C:25]([O:27][CH2:28][CH3:29])=[O:26])=[O:23])=[CH:37][CH:38]=1

참가 물질

4

반응물 3

HCID 6422Trifluoroacetic acidHCID 14797Potassium HydroxideHCID 20198261tert-Butyl ethyl 4-[14-(trimethylsilyl)tetradecylamino]benzoylmalonate

생성물 1

HCID 20198260Ethyl 4-[14-(trimethylsilyl)tetradecylamino]benzoylacetate

실험 절차

A solution of 3.0 g. of tert-butyl ethyl 4-[14-(trimethylsilyl)tetradecylamino]benzoylmalonate and 10 ml. of trifluoroacetic acid is warmed with stirring for 3 hours. The solution is poured onto ice and neutralized with potassium hydroxide. The resulting precipitate is collected by filtration, washed with water and dried. Recrystallization affords the product as a white solid.

후처리

  1. filtrationThe resulting precipitate is collected by filtration
  2. washwashed with water
  3. customdried
  4. customRecrystallization

출처 및 근거

ORD 기록
ord-72e4124e5c5e4f489fda6adeebfa3568
출처 데이터셋
uspto-grants-1987_06
특허 번호
US04670421

연결된 노트

불러오는 중…