Hydrochloric Acid → HCID 20198263, 화합물

HRID 652042노트

반응식

HRID 652042 반응식
[CH3:1][Si:2]([CH3:33])([CH3:32])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][NH:17][C:18]1[CH:31]=[CH:30][C:21]([C:22]([CH2:24][CH2:25][C:26]([O:28]C)=[O:27])=[O:23])=[CH:20][CH:19]=1.[OH-].[K+].C(O)C.Cl>O>[CH3:33][Si:2]([CH3:1])([CH3:32])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][NH:17][C:18]1[CH:19]=[CH:20][C:21]([C:22]([CH2:24][CH2:25][C:26]([OH:28])=[O:27])=[O:23])=[CH:30][CH:31]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 702Ethanol2회HCID 14797Potassium HydroxideHCID 20198232HCID 20198232, 화합물

생성물 1

HCID 20198263HCID 20198263, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of 5.4 g. of methyl 3-[4-[14-(trimethylsilyl)tetradecylamino]benzoyl]propionate is stirred with 5.4 g. of potassium hydroxide in 100 ml. of 95% ethanol for 3 hours at reflux. The reaction mixture is cooled, diluted with 50 ml. of ethanol and 100 ml. of water, and neutralized with hydrochloric acid. The solution is cooled to room temperature and filtered. The white solid is washed with 50% aqueous ethanol and dried. The product is recrystallized to yield 3-[4-[14-(trimethylsilyl)tetradecylamino]benzoyl]propionic acid as a white crystalline solid.

후처리

  1. temperatureThe reaction mixture is cooled
  2. additiondiluted with 50 ml
  3. filtrationfiltered
  4. washThe white solid is washed with 50% aqueous ethanol
  5. customdried
  6. customThe product is recrystallized

출처 및 근거

ORD 기록
ord-accc9ce6d8504295b2dfd32400a04e9e
출처 데이터셋
uspto-grants-1987_06
특허 번호
US04670421

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