1-(4-Chlorophenyl)-2-butyn-1-ol → (Z)-1-(4-chlorophenyl)-2-buten-1-ol

HRID 65235

반응식

HRID 65235 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([OH:12])[C:9]#[C:10][CH3:11])=[CH:4][CH:3]=1>[Pd].CC([O-])=O.CC([O-])=O.[Pb+2]>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([OH:12])/[CH:9]=[CH:10]\[CH3:11])=[CH:6][CH:7]=1

참가 물질

3

반응물 1

HCID 201883391-(4-Chlorophenyl)-2-butyn-1-ol

생성물 1

HCID 67901371(Z)-1-(4-chlorophenyl)-2-buten-1-ol

시약·촉매·용매 1

HCID 131709914Lindlars catalyst촉매

실험 절차

Under nitrogen, hydrogenate a mixture of 10 g (0.055 mole) of 1-(4-chlorophenyl)-2-butyn-1-ol and 0.6 g Lindlar catalyst. Following the reaction vic NMR the reaction is complete in about two days. The hydrogenation is stopped and the reaction stirred under N2 at room temperature overnight. Filter off the catalysts, wash with methylene chloride combine the filtrate and evaporate to yield the title compound.

후처리

  1. filtrationFilter off the catalysts
  2. washwash with methylene chloride
  3. customevaporate

출처 및 근거

ORD 기록
ord-1ba35f007e7240af90d3407e16dabfe8
출처 데이터셋
uspto-grants-1986_09
특허 번호
US04613609

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