Phosphoric Acid → HCID 20197207, 화합물

반응식

[ClH:1].[CH2:2]([NH:6][CH:7]1[CH2:13][CH:12](O)[C:11]2[CH:15]=[CH:16][CH:17]=[CH:18][C:10]=2[O:9][CH2:8]1)[CH2:3][CH2:4][CH3:5].P(=O)(O)(O)O>>[ClH:1].[CH2:2]([NH:6][CH:7]1[CH:13]=[CH:12][C:11]2[CH:15]=[CH:16][CH:17]=[CH:18][C:10]=2[O:9][CH2:8]1)[CH2:3][CH2:4][CH3:5]

참가 물질

반응물 2

HCID 1004Phosphoric Acid

HCID 20197204HCID 20197204, 화합물

생성물 1

HCID 20197207HCID 20197207, 화합물수율 84.7%

실험 절차

15.3 g 3-butylamino-2,3,4,5-tetrahydro-1-benzoxepin-5-ol hydrochloride were stirred for four hours at room temperature in 80 ml of an 85 percent aqueous phosphoric acid solution. Subsequently, the solution was poured over 100 g of ice, and the mixture was worked up as described in Example 1. 12.1 g of 3-butylamino-2,3-dihydro-1-benzoxepine hydrochloride were obtained. Melting point: 138 degrees C.

출처 및 근거

ORD 기록: ord-9e4f83ee5949424f8a5eee9fb41b59a5
출처 데이터셋: uspto-grants-1987_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04672062

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